The department was established in 1926. Sri T.U.Chacko was the founder Head. Eminent teachers like Sri I.M.Rao, Sri Ch. Hanumantha Rao, Sri A. Kameswara Rao Sri G.Sri Rama Murthy, Sri Md. Iqbal Ahmad and their followers put all their efforts to uplift the department. In early days, the department offered P.U.C. and B.Sc. (Hons.). Later it offered Intermediate and B.Sc.(Botany) courses, till bifurcation of the Higher Education in 1993. The department is anchoring Microbiology since 2004.
The department produced a galaxy of eminent Botanists who spread over the globe and bringing laurels to their alma-mater. Prof.Rolla S.Rao, Prof. J.Vekateswarlu, Prof. H.Maheswari Devi, Prof.Y.S.R.K.Sarma, Prof.V.R.S.Talpasai, Padma Shri Dr. M.V.Rao, Prof. Piratla N.Rao, Prof. Panuganti N.Rao, Prof. V. Seshavataram, Dr.Andra S.Murthy, Sri A.R.K.Sastry, Prof. Vatsavaya S. Raju are some among the alumni.
The department has well equipped Tissue Culture laboratory. It has good Botanical gardens with many interesting plant species and herbarium collections since 1925.